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Related Experiment Videos

Red blood cell substitutes.

T M Chang1

  • 1Artificial Cells and Organs Research Centre, Department of Physiology, McGill University, Montreal, Canada.

Bailliere'S Best Practice & Research. Clinical Haematology
|December 5, 2000
PubMed
Summary
This summary is machine-generated.

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Preface

Bailliere's best practice & research. Clinical haematology·2000
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Index

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Soluble polymerized hemoglobin (polyhaemoglobin) is being tested in clinical trials as a universal donor oxygen carrier. Newer versions aim to reduce oxidative stress and prolong circulation time for various medical applications.

Area of Science:

  • Biomedical Engineering
  • Hematology
  • Emergency Medicine

Background:

  • Soluble polymerized hemoglobin (polyhaemoglobin) is advancing to Phase III clinical trials.
  • Current applications include trauma and other surgeries, with patients receiving up to 10 liters.

Observation:

  • Polyhaemoglobin offers a storage life exceeding one year and can be sterilized.
  • Lacking blood group antigens, it functions as a universal donor oxygen carrier.
  • Circulation half-life is approximately 24 hours, suitable for peri-operative use.

Findings:

  • New polyhaemoglobin formulations incorporate superoxide dismutase-catalase to mitigate ischemia-reperfusion injury by reducing oxygen radicals.
  • Recombinant human hemoglobins are under investigation, including variants with low nitric oxide affinity.

Related Experiment Videos

  • Artificial red blood cells, such as hemoglobin liposomes and nanocapsules, are being developed to extend circulation time.

    • Implications:

    • These advancements in hemoglobin-based oxygen carriers (HBOCs) and artificial red blood cells hold significant promise for transfusion medicine and critical care.
    • Potential applications span emergency medicine, surgery, and treatment of conditions involving oxygen deprivation.
    • Further development of HBOCs and related technologies could reduce reliance on traditional blood transfusions.