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Related Experiment Videos

Percolation thresholds in ultrasound compacted tablets.

I Caraballo1, M Millán, A Fini

  • 1Departamento de Farmacia y Tecnología Farmacéutica, Universidad de Sevilla, C/ Profesor García González s/n, 41012, Sevilla, Spain. isidoro@cica.es

Journal of Controlled Release : Official Journal of the Controlled Release Society
|December 5, 2000
PubMed
Summary

Ultrasound compaction of drug matrices significantly lowers the excipient percolation threshold by transforming Eudragit RS-PM into a continuum phase. This impacts drug release kinetics and tablet properties, differing from traditional compaction methods.

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Area of Science:

  • Pharmaceutical Technology
  • Materials Science
  • Drug Delivery Systems

Background:

  • Understanding percolation thresholds is crucial for designing controlled drug release systems.
  • Eudragit RS-PM is a common inert excipient in tablet formulations.
  • Ultrasound-assisted compaction offers novel processing possibilities for pharmaceutical matrices.

Purpose of the Study:

  • To investigate the impact of ultrasound-assisted compaction on percolation thresholds in drug-excipient matrix systems.
  • To compare the percolation behavior of KCl and Eudragit RS-PM under ultrasound versus traditional compaction.
  • To correlate technological properties and release kinetics with percolation phenomena.

Main Methods:

  • Preparation of 20 matrix systems with varying KCl (drug model) and Eudragit RS-PM (excipient) content.

Related Experiment Videos

  • Compaction using ultrasound-assisted (US) and traditional eccentric machines.
  • Examination of drug release behavior and kinetic parameters (intrinsic dissolution).
  • Measurement of tablet technological properties (total porosity).
  • Estimation of percolation thresholds for both KCl and Eudragit RS-PM.

    • Main Results:

    • Ultrasound compaction resulted in a lower excipient percolation threshold (13.4–20.2% v/v) compared to traditional tablets.
    • Ultrasound-induced thermoplastic deformation of Eudragit RS-PM created a continuum phase.
    • Percolation threshold for KCl was higher in US tablets (58.6–61.0% v/v) than traditional tablets (26.7–42.2% v/v).
    • The findings support a continuum percolation model for US-compacted systems.

    Conclusions:

    • Ultrasound-assisted compaction significantly alters the percolation behavior of drug-excipient systems.
    • The thermoplasticity of Eudragit RS-PM under ultrasound is key to forming a continuum phase, affecting tablet properties.
    • Differences in percolation thresholds influence drug release and tablet characteristics, offering new formulation design strategies.