Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

RNA as a target for small molecules.

S J Sucheck1, C H Wong

  • 1Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Current Opinion in Chemical Biology
|December 5, 2000
PubMed
Summary

RNA offers a novel drug discovery target by interfering with the translational process. Small molecules can bind mRNA sequence-specifically, impacting pathogen survival and disease progression.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synergistic activities of Panobinostat and doxorubicin in soft tissue sarcomas.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2024
Same author

Atypical metatarsal fracture in a Chinese postmenopausal woman with osteoporosis on long-term denosumab: a case report.

Hong Kong medical journal = Xianggang yi xue za zhi·2024
Same author

Ticagrelor was associated with lower fracture risk than clopidogrel in the dual anti-platelet regimen among patients with acute coronary syndrome treated with percutaneous coronary intervention.

Journal of endocrinological investigation·2023
Same author

Preclinical evaluation of the VEGF/Ang2 bispecific nanobody BI 836880 in nasopharyngeal carcinoma models.

Investigational new drugs·2023
Same author

Thermal Disorder in Finite-Length Carbon Nanowire.

International journal of molecular sciences·2023
Same author

Synergistic activities of the histone deacetylase inhibitors with conventional cytotoxic chemotherapies in angiosarcomas.

Investigational new drugs·2022

Area of Science:

  • Molecular Biology
  • Drug Discovery
  • RNA Therapeutics

Background:

  • Traditional drug discovery targets protein binding sites.
  • RNA plays critical roles in pathogen survival and disease progression.
  • Accumulating structural and functional RNA information enables new therapeutic strategies.

Purpose of the Study:

  • To highlight RNA as an alternative drug discovery target.
  • To explore the potential of small molecules targeting the translational process.
  • To discuss RNA sequence-specific binding for therapeutic intervention.

Main Methods:

  • Review of RNA's role in biological processes.
  • Analysis of small molecule interactions with mRNA.
  • Case study of aminoglycoside antibiotics binding to 16S ribosomal RNA.

Main Results:

  • RNA targeting offers an upstream approach to drug discovery.
  • Small molecules can specifically inhibit mRNA translation.
  • Aminoglycoside-RNA interactions provide a model for RNA-targeted drug development.

Conclusions:

  • RNA presents a promising and underexplored target for novel therapeutics.
  • Sequence-specific small molecules can modulate RNA function.
  • Further research into RNA-targeted therapies is warranted.

Related Experiment Videos