Related Experiment Video
Updated: Aug 8, 2026
Screening of Axonal Degeneration in Carpal Tunnel Syndrome Using Ultrasonography and Nerve Conduction Studies
Published on: January 11, 2019
Optimizing the number of tests for carpal tunnel syndrome
L R Robinson1, P J Micklesen, L Wang
1Department of Rehabilitation Medicine, Box 359740, Harborview Medical Center, 325 Ninth Avenue, Seattle, Washington 98104, USA. lorenzo@u.washington.edu
Abstract:
The combined sensory index (CSI), the sum of three latency differences, median-ulnar across the palm (palmdiff), median-ulnar to the ring finger (ringdiff), and median-radial to the thumb (thumbdiff), has higher sensitivity and reliability for carpal tunnel syndrome than individual tests. The objective in this study was to develop an approach that minimizes testing but maximizes accuracy. We retrospectively studied 300 hands. There were endpoints for individual tests that confidently predicted the CSI; for ranges between these endpoints, further testing was required. These ranges were: palmdiff 0-0.3 ms; ringdiff 0.1-0.4 ms; and thumbdiff 0.2-0.7 ms. One may use a strategy in which more tests are performed when results are in these ranges. This approach can allow accurate diagnosis with fewer tests when values are extreme, yet uses the greater diagnostic power of more tests when values are midrange.
