Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Extra cellular matrix features in human meninges.

S Montagnani1, C Castaldo, F Di Meglio

  • 1Dipartimento di Scienze Biomorfologiche e funzionali, Università degli Studi Federico II, Napoli. montagna@unina.it

Italian Journal of Anatomy and Embryology = Archivio Italiano Di Anatomia Ed Embriologia
|December 5, 2000
PubMed
Summary

Fetal meninges show higher levels of laminin and tenascin in their extracellular matrix compared to adult meninges. These proteins may be newly produced in meningiomas, unlike their biophysical role in adult tissues.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The concept of bank tissue applied to post bariatric abdominoplasty: The use of autologous dermal mesh for abdominal diastasis repair.

Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2022
Same author

Measurement of electromagnetic waves from runaway electrons.

The Review of scientific instruments·2022
Same author

First Intrashot Observation of Runaway-Electron-Driven Instabilities at the Lower-Hybrid Frequency Range under ITER-Relevant Plasma-Wave Dispersion Conditions.

Physical review letters·2022
Same author

MicroRNA-Mediated Direct Reprogramming of Human Adult Fibroblasts Toward Cardiac Phenotype.

Frontiers in bioengineering and biotechnology·2020
Same author

Radio-frequency current drive for thermonuclear fusion reactors.

Scientific reports·2018
Same author

Advances in the FTU collective Thomson scattering system.

The Review of scientific instruments·2016

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Pathology

Background:

  • The meninges, protective membranes surrounding the brain and spinal cord, undergo developmental changes.
  • Extracellular Matrix (ECM) components, including collagenous and non-collagenous proteins, are crucial for tissue structure and function.
  • Laminin and tenascin are key non-collagenous ECM proteins involved in cell migration and morphogenesis.

Purpose of the Study:

  • To investigate age-related changes in ECM composition in human meninges.
  • To compare the expression of laminin and tenascin in fetal, adult, and meningioma tissues.
  • To explore the potential role of these proteins in meningioma development.

Main Methods:

  • Human fetal and adult normal meninges were collected.

Related Experiment Videos

  • Immunohistochemistry was employed to analyze protein expression and distribution.
  • Meningioma specimens were also studied to compare with normal tissues.

    • Main Results:

    • Significant differences in the amount and distribution of ECM proteins were observed between fetal and adult meninges.
    • Laminin and tenascin expression was notably higher in fetal meninges than in adult meninges.
    • Meningiomas showed evidence suggesting potential de novo synthesis of laminin and tenascin.

    Conclusions:

    • Laminin and tenascin play a more prominent role in fetal meningeal development, potentially influencing cell migration and neuronal morphogenesis.
    • The elevated expression of these proteins in meningiomas suggests a possible role in tumor pathogenesis.
    • In adult meninges, laminin and tenascin may primarily contribute to biophysical properties.