New roles for structure in biology and drug discovery

The mutational pattern of primary lymphoma of the central nervous system determined by whole-exome sequencing.

Leukemia·2014

Hb M Dothan [beta 25/26 (B7/B8)/(GGT/GAG-->GAG//Gly/Glu-->Glu]; a new mechanism of unstable methemoglobin variant and molecular characteristics.

Blood cells, molecules & diseases·2009

Fold recognition from sequence comparisons.

Proteins·2002

Predicting function from structure: examples of the serine protease inhibitor canonical loop conformation found in extracellular proteins.

Computers & chemistry·2002

GABA(B2) is essential for g-protein coupling of the GABA(B) receptor heterodimer.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2001

Exon structure conservation despite low sequence similarity: a relic of dramatic events in evolution?

The EMBO journal·2001

Recognition and processing of the origin of transfer DNA by conjugative relaxase TrwC.

Nature structural biology·2003

The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes.

Nature structural biology·2003

Germline antibody recognition of distinct carbohydrate epitopes.

Nature structural biology·2003

Homodirectional changes in transcriptome composition and mRNA translation induced by rapamycin and heat shock.

Nature structural biology·2003

Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster.

Nature structural biology·2003

Reovirus polymerase lambda 3 localized by cryo-electron microscopy of virions at a resolution of 7.6 A.

Nature structural biology·2003

Computational Design and Theoretical Evaluation of Novel Heterocyclic Energetic Materials Based on 5-H-Imidazo-[4,5-c]-Pyridazine and 1,2,4-Triazolo-[4,3-a]-Pyrazine Scaffolds.

Journal of computational chemistry·2026

Dimerization and Ligand Binding Rewire Allosteric Networks in SARS-CoV-2 Main Protease.

Biophysical journal·2026

DyProL: Dynamic Ensemble Representation Learning for Protein-Nucleic Acid Binding Site Prediction.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Lipidomic Profile Reconstruction of Therapeutic Membrane Targets Using Physics-Based Optimization with Limited Activity Data.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

[Construction and application of organoid models in traditional Chinese medicine research].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2026

Similarity-Adaptive interaction routing for Drug-Target affinity prediction.

Journal of biomedical informatics·2026

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New roles for structure in biology and drug discovery

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The mutational pattern of primary lymphoma of the central nervous system determined by whole-exome sequencing.

Hb M Dothan [beta 25/26 (B7/B8)/(GGT/GAG-->GAG//Gly/Glu-->Glu]; a new mechanism of unstable methemoglobin variant and molecular characteristics.

Fold recognition from sequence comparisons.

Predicting function from structure: examples of the serine protease inhibitor canonical loop conformation found in extracellular proteins.

GABA(B2) is essential for g-protein coupling of the GABA(B) receptor heterodimer.

Exon structure conservation despite low sequence similarity: a relic of dramatic events in evolution?

Recognition and processing of the origin of transfer DNA by conjugative relaxase TrwC.

The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes.

Germline antibody recognition of distinct carbohydrate epitopes.

Homodirectional changes in transcriptome composition and mRNA translation induced by rapamycin and heat shock.

Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster.

Reovirus polymerase lambda 3 localized by cryo-electron microscopy of virions at a resolution of 7.6 A.

Computational Design and Theoretical Evaluation of Novel Heterocyclic Energetic Materials Based on 5-H-Imidazo-[4,5-c]-Pyridazine and 1,2,4-Triazolo-[4,3-a]-Pyrazine Scaffolds.

Dimerization and Ligand Binding Rewire Allosteric Networks in SARS-CoV-2 Main Protease.

DyProL: Dynamic Ensemble Representation Learning for Protein-Nucleic Acid Binding Site Prediction.

Lipidomic Profile Reconstruction of Therapeutic Membrane Targets Using Physics-Based Optimization with Limited Activity Data.

[Construction and application of organoid models in traditional Chinese medicine research].

Similarity-Adaptive interaction routing for Drug-Target affinity prediction.

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New roles for structure in biology and drug discovery

Related Concept Videos

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