New roles for structure in biology and drug discovery

The mutational pattern of primary lymphoma of the central nervous system determined by whole-exome sequencing.

Leukemia·2014

Hb M Dothan [beta 25/26 (B7/B8)/(GGT/GAG-->GAG//Gly/Glu-->Glu]; a new mechanism of unstable methemoglobin variant and molecular characteristics.

Blood cells, molecules & diseases·2009

Fold recognition from sequence comparisons.

Proteins·2002

Predicting function from structure: examples of the serine protease inhibitor canonical loop conformation found in extracellular proteins.

Computers & chemistry·2002

GABA(B2) is essential for g-protein coupling of the GABA(B) receptor heterodimer.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2001

Exon structure conservation despite low sequence similarity: a relic of dramatic events in evolution?

The EMBO journal·2001

Recognition and processing of the origin of transfer DNA by conjugative relaxase TrwC.

Nature structural biology·2003

The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes.

Nature structural biology·2003

Germline antibody recognition of distinct carbohydrate epitopes.

Nature structural biology·2003

Homodirectional changes in transcriptome composition and mRNA translation induced by rapamycin and heat shock.

Nature structural biology·2003

Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster.

Nature structural biology·2003

Reovirus polymerase lambda 3 localized by cryo-electron microscopy of virions at a resolution of 7.6 A.

Nature structural biology·2003

The shelved pipeline: AI can find strategically abandoned medicines and bring them to patients.

Drug discovery today·2026

Structure-based design of a 1H-Tetrazole-containing scaffold for Caspase-1 inhibition: Synthesis, biological evaluation, and preliminary in Vivo studies.

Bioorganic & medicinal chemistry·2026

Potential Relationship Between Macrophage Inflammatory Protein-1β and Diabetic Kidney Disease: A Multi-Model Study.

International journal of general medicine·2026

A viscosity-tunable microgel-in-sol phase for localized inner ear delivery of small hydrophilic drug.

Materials today. Bio·2026

Receptor-mimicking antibodies retain neutralization of recent SARS-CoV-2 variants.

Biosafety and health·2026

Expanding Quantitative Medicines' Reach: Systems and Methods to Enhance R&D Productivity and Decision-Making in the Agentic-Era.

Clinical and translational science·2026

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New roles for structure in biology and drug discovery

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The mutational pattern of primary lymphoma of the central nervous system determined by whole-exome sequencing.

Hb M Dothan [beta 25/26 (B7/B8)/(GGT/GAG-->GAG//Gly/Glu-->Glu]; a new mechanism of unstable methemoglobin variant and molecular characteristics.

Fold recognition from sequence comparisons.

Predicting function from structure: examples of the serine protease inhibitor canonical loop conformation found in extracellular proteins.

GABA(B2) is essential for g-protein coupling of the GABA(B) receptor heterodimer.

Exon structure conservation despite low sequence similarity: a relic of dramatic events in evolution?

Recognition and processing of the origin of transfer DNA by conjugative relaxase TrwC.

The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes.

Germline antibody recognition of distinct carbohydrate epitopes.

Homodirectional changes in transcriptome composition and mRNA translation induced by rapamycin and heat shock.

Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster.

Reovirus polymerase lambda 3 localized by cryo-electron microscopy of virions at a resolution of 7.6 A.

The shelved pipeline: AI can find strategically abandoned medicines and bring them to patients.

Structure-based design of a 1H-Tetrazole-containing scaffold for Caspase-1 inhibition: Synthesis, biological evaluation, and preliminary in Vivo studies.

Potential Relationship Between Macrophage Inflammatory Protein-1β and Diabetic Kidney Disease: A Multi-Model Study.

A viscosity-tunable microgel-in-sol phase for localized inner ear delivery of small hydrophilic drug.

Receptor-mimicking antibodies retain neutralization of recent SARS-CoV-2 variants.

Expanding Quantitative Medicines' Reach: Systems and Methods to Enhance R&D Productivity and Decision-Making in the Agentic-Era.

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New roles for structure in biology and drug discovery

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