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Structural genomics projects in Japan.

S Yokoyama1, H Hirota, T Kigawa

  • 1Genomic Sciences Center, RIKEN Yokohama Institute, Tsurumi, Japan. yokoyama@biochem.s.u-tokyo.ac.jp

Nature Structural Biology
|December 5, 2000
PubMed
Summary

Japan

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Area of Science:

  • Structural biology
  • Genomics
  • Biochemistry

Background:

  • Two significant structural genomics projects are active in Japan.
  • These initiatives aim to elucidate protein structures and functions.

Purpose of the Study:

  • To outline the objectives and scope of Japan's major structural genomics initiatives.
  • To highlight the different focuses of the RIKEN Structural Genomics Initiative and the Biological Information Research Center project.

Main Methods:

  • X-ray crystallography
  • Nuclear Magnetic Resonance (NMR) spectroscopy
  • Functional analysis of proteins

Main Results:

  • The RIKEN Structural Genomics Initiative targets bacterial, mammalian, and plant proteins.

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  • The Biological Information Research Center project concentrates on human membrane proteins.

    • Conclusions:

    • Japan hosts leading structural genomics efforts.
    • These projects contribute to understanding protein structures and functions across diverse organisms and protein types.