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From structure to function: approaches and limitations
J M Thornton1, A E Todd, D Milburn
1Biochemistry & Molecular Biology Dept, University College, London, UK. thornton@biochem.ucl.ac.uk
Nature Structural Biology
|December 5, 2000
Abstract:
This review presents a summary of current approaches to extract functional information from structural data on proteins and their complexes. While structural homologs may reveal possible biochemical functions (which may be hidden at the sequence level), elucidating the exact biological role of a protein in vivo will only be possible by including other results, such as data on expression and localization.