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Bioactive triterpenoids from the stem bark of Picea glehni
R Tanaka1, Y Kinouchi, H Tokuda
1Department of Medicinal Chemistry, Osaka University of Pharmaceutical Sciences, Japan. tanakar@oysun01.oups.ac.jp
Planta Medica
|December 6, 2000
Abstract:
Two new triterpenoids, 3 alpha-methoxyserrat-14-en-21 beta-yl formate (1), and 24-methylcycloartenone (2), were isolated from the stem bark of Picea glehni (Fr. Schm.) Masters together with three known triterpenoids, 3 alpha-methoxyserrat-14-en-21 beta-ol, 3 beta-methoxyserrat-14-en-21 beta-ol, and piceanonol A. Compounds 1, 2, and a synthetic sample, 3 alpha-methoxyserrat-13-en-21 beta-yl formate showed potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).