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Hypnopompic hallucinations with donepezil.

G A Yorston1, R Gray

  • 1Department of Old Age Psychiatry, Udston Hospital, Hamilton, UK. Graeme@yorston.fsbusiness.co.uk

Journal of Psychopharmacology (Oxford, England)
|December 6, 2000
PubMed
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This case study describes hypnopompic hallucinations in a patient taking donepezil. Acetylcholinesterase inhibitors can impact sleep, highlighting the need to assess sleep in patients on these Alzheimer's disease medications.

Area of Science:

  • Neurology
  • Sleep Medicine
  • Pharmacology

Background:

  • Alzheimer's Disease (AD) is characterized by cognitive decline and often exhibits electroencephalogram (EEG) abnormalities.
  • Acetylcholinesterase inhibitors (AChEIs) are a primary pharmacotherapy for AD, aiming to improve cholinergic neurotransmission.

Observation:

  • A specific case of hypnopompic hallucinations, a form of sleep-related hallucination, is presented in a patient undergoing donepezil treatment.
  • This adverse event occurred in the context of known EEG and sleep disturbances associated with both AD and AChEI therapy.

Findings:

  • Donepezil, an AChEI, may be associated with the emergence or exacerbation of specific sleep-related phenomena, such as hypnopompic hallucinations.
  • AChEIs are known to influence rapid eye movement (REM) sleep and overall alertness, suggesting a potential mechanism for sleep disturbances.

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Implications:

  • Clinicians should consider sleep disturbances, including hallucinations, as potential side effects in patients treated with donepezil and other AChEIs.
  • Systematic assessment of sleep patterns and quality is crucial for patients with Alzheimer's Disease receiving AChEI therapy to optimize treatment outcomes and patient well-being.