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Related Experiment Videos

Electrostatic control of phospholipid polymorphism.

Y S Tarahovsky1, A L Arsenault, R C MacDonald

  • 1Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA.

Biophysical Journal
|December 7, 2000
PubMed
Summary
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Mixtures of anionic cardiolipin and cationic phospholipids exhibit a sequence of nonlamellar phases, including hexagonal and cubic structures, controlled by charge ratio. These lipid phase transitions have potential biological and technical applications.

Area of Science:

  • Biochemistry
  • Materials Science

Background:

  • Phospholipids are key components of cell membranes.
  • Cardiolipin (anionic) and ethylphosphocholine (cationic) derivatives exhibit distinct phase behaviors individually.

Purpose of the Study:

  • To investigate the polymorphic phase behavior of mixtures of anionic cardiolipin and a cationic phospholipid derivative.
  • To understand how charge ratio influences lipid phase transitions.

Main Methods:

  • Freeze-fracture electron microscopy
  • Small-angle X-ray diffraction

Main Results:

  • Lipid mixtures showed a symmetrical sequence of nonlamellar phases dependent on charge ratio.
  • Equimolar mixtures formed inverted hexagonal (H(II)) phases.

Related Experiment Videos

  • Excess charge resulted in bicontinuous cubic and sponge-like structures.
  • Cubic phases resembled those found in cellular organelles.

    • Conclusions:

    • Interactions between cationic and anionic lipid moieties control polymorphic phase transitions.
    • Lipid phase behavior is tunable via charge ratio.
    • Isothermal interconversion of lipid phases has biological and technical implications.