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Analysis of longitudinal data from twins
R M Huggins1, N H Hoang, D Z Loesch
1Department of Statistical Science, La Trobe University, Bundoora, Australia. r.huggins@latrobe.edu.au
Genetic Epidemiology
|December 7, 2000
Abstract:
Longitudinal data from twin pairs may be used to determine how the genetic effects influencing a quantitative trait change with age. Here a model for mixed longitudinal data of Huggins and Loesch [1998] on unrelated individuals is extended to twin studies. The model is fitted using robust statistical methods and a bootstrap procedure is proposed to estimate the percentiles. The method is applied to longitudinal twin data on body mass index in male and female twin pairs aged 5-18 years.