The levonorgestrel intrauterine system: therapeutic aspects

Area of Science:

• Gynecology
• Reproductive Medicine
• Pharmacology

Background:

• The levonorgestrel-releasing intrauterine system (LNG IUS) is known to reduce menstrual bleeding.
• Its mechanism involves local action of levonorgestrel (LNG) on the endometrium, suppressing active compounds and stimulating regulatory proteins.

Purpose of the Study:

• To evaluate the effectiveness and long-term impact of the LNG IUS in managing heavy menstrual bleeding and related conditions.
• To assess its role in iron deficiency anemia and endometrial protection during hormone replacement therapy.

Main Methods:

• Review of studies demonstrating the efficacy of LNG IUS in reducing menstrual blood loss.
• Analysis of data on the duration of therapeutic effect and patient outcomes.
• Assessment of its use in menorrhagia, iron deficiency anemia, and hormone replacement therapy.

Main Results:

• LNG IUS reduces menstrual blood loss by over 90% within one year, with effects lasting over five years.
• It improves iron balance and hemoglobin levels, effectively treating iron deficiency anemia.
• It is highly accepted for endometrial protection in hormone replacement therapy, often leading to amenorrhea.

Conclusions:

• The LNG IUS is a highly effective, long-term treatment for menorrhagia, improving anemia and preserving fertility.
• It offers a safe and well-tolerated alternative to invasive procedures like hysterectomy.
• It is a valuable option for endometrial protection in menopausal hormone replacement therapy.