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[Effect of ammonium succinate on pharmacological effects of acetylsalicylic acid]
A S Saratikov1, A P Bulatnikov, A I Vengerovskiĭ
1Pharmacology Department, Siberian Medical University, Tomsk, Russia.
Abstract:
Ammonia succinate potentiates the main pharmacological properties and reduces the toxic effects (ulcerogenic action and general toxicity) of acetylsalicylic acid. The new preparation astam, representing a combination of acetylsalicylic acid with ammonia succinate in a 2:1 ratio, is proposed. Astam exhibits antiexudative, capillary-reinforcing, antiproliferative, pain-relieving, antipyretic, antiaggregant, and antioxidant properties. In addition, the drug inhibits the development of structural-metabolic disorders in the case of chronic immune inflammation of joints and various internal organs.
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