Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Specific versus nonspecific brain activity in a parametric N-back task.

J M Jansma1, N F Ramsey, R Coppola

  • 1Department of Psychiatry, HP A01.126, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands. j.m.jansma@azu.nl

Neuroimage
|December 9, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Robotic subtotal gastrectomy with Hugo™ robotic-assisted surgery (RAS) system: first report on a case series.

International journal of surgery case reports·2026
Same author

High-density electrocorticography reveals sensorimotor cortex engagement in two distinct sites with different roles during audiovisual, audio, and visual speech perception.

NeuroImage·2025
Same author

The effect of perceived auditory feedback on speech Brain-Computer Interface decoding performance.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2025
Same author

Don't put words in my mouth: Speech perception can generate False Positive activation of a speech BCI.

medRxiv : the preprint server for health sciences·2024
Same author

Neurotechnology in criminal justice: key points for neuroscientists and engineers.

Journal of neural engineering·2024
Same author

Reliability and validity of DTI-based indirect disconnection measures.

NeuroImage. Clinical·2023
Same journal

Decoding neuronal criticality firing patterns for large brain based EEG models.

NeuroImage·2026
Same journal

Segmentation of the parasagittal dura mater on multi-center 3D-FLAIR MRI.

NeuroImage·2026
Same journal

Spatial frequency channels implement a mental ruler in spatial vision.

NeuroImage·2026
Same journal

Exploring the Link Between Intravoxel Incoherent Motion Measured Brain Diffusivity During Wakefulness and Sleep Macrostructure in the Elderly.

NeuroImage·2026
Same journal

Closed-loop adaptation of transcranial magnetic stimulation intensity with electroencephalography feedback.

NeuroImage·2026
Same journal

Volumetric postmortem MRI of the medial temporal lobe in Alzheimer's disease and related disorders: methodological advances and implications for in vivo biomarker development.

NeuroImage·2026
See all related articles

This study used fMRI to map brain activity during working memory tasks. It identified specific workload-related brain activity and general task-related activity in frontal and parietal regions.

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Functional Magnetic Resonance Imaging (fMRI)

Background:

  • Working memory involves complex cognitive processes.
  • Distinguishing specific workload-related activity from general task-related activity is crucial for understanding cognitive function.
  • Functional magnetic resonance imaging (fMRI) is a key tool for investigating brain activity patterns.

Purpose of the Study:

  • To analytically distinguish nonspecific task-related processes from specific workload processes using fMRI.
  • To examine cerebral activity patterns associated with increasing mental load in a working memory task.
  • To develop and apply an analytical strategy for separating load-sensitive and load-insensitive brain activity.

Main Methods:

  • Utilized functional magnetic resonance imaging (fMRI) with a 3D-PRESTO pulse sequence.

Related Experiment Videos

  • Employed a two-step multiple regression algorithm to analyze fMRI data.
  • Healthy volunteers performed a spatial n-back task at four difficulty levels.

    • Main Results:

    • Load-sensitive and load-insensitive activity were identified in the dorsolateral-prefrontal cortex, parietal cortex, and anterior cingulate, predominantly bilaterally.
    • The left primary sensorimotor cortex showed primarily load-insensitive activity.
    • Load-sensitive activity correlates with working memory functions, while load-insensitive activity relates to supportive cognitive functions.

    Conclusions:

    • Specific and nonspecific working memory processes colocalize within multiple frontal and parietal brain regions.
    • The analytical strategy effectively separates load-sensitive and load-insensitive brain activity while maintaining spatial resolution.
    • Findings have implications for research into psychiatric disorders affecting working memory.