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Synthesis of the sialidase inhibitor siastatin B
1Department of Chemistry; Rutgers-The State University of New Jersey, 610 Taylor Road, Piscataway, New Jersey 08854-8087, USA. knapp@rutchem.rutgers.edu
Organic Letters
|December 12, 2000
Abstract:
[structure] The resolved piperidinecarboxylate (R)-7 was converted to siastatin B (1) by an efficient and stereoselective sequence that includes a bromo-beta-lactonization and an N-acyliminium azidation. Two analogues (3 and 4) of siastatin were also prepared.