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Liver tumors.

M D Stringer1

  • 1Children's Liver Centre, St James University Hospital, Leeds, UK.

Seminars in Pediatric Surgery
|December 12, 2000
PubMed
Summary
This summary is machine-generated.

Pediatric liver tumors are rare but diverse. Accurate diagnosis is achievable with imaging and biopsy, with hepatoblastoma showing improved survival rates due to modern treatments.

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Area of Science:

  • Pediatric oncology
  • Hepatology
  • Diagnostic imaging

Background:

  • Liver tumors in children are uncommon, varied, and can affect any age, including fetuses.
  • Abdominal distension or a palpable mass are common presenting symptoms.

Purpose of the Study:

  • To review the diagnosis and management of pediatric liver tumors.
  • To highlight advancements in treating hepatoblastoma and challenges in hepatocellular cancer.

Main Methods:

  • Diagnostic modalities include ultrasound, CT/MRI, liver biopsy, and tumor markers.
  • Treatment strategies involve chemotherapy, surgical resection, and liver transplantation.

Main Results:

  • Hepatoblastoma, the most frequent malignant liver tumor in Western countries, now has over 80% disease-free survival.

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  • Benign tumors include hemangiomas, mesenchymal hamartomas, focal nodular hyperplasia, and adenomas.
  • Hepatocellular cancer in children remains a therapeutic challenge with limited progress.

    • Conclusions:

    • Accurate preoperative diagnosis of pediatric liver tumors is feasible.
    • Multimodal treatment has significantly improved outcomes for hepatoblastoma.
    • Further research is needed for better management of pediatric hepatocellular cancer.