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New protopine alkaloids from Aristolochia constricta reduce morphine withdrawal in vitro
A Capasso1, N De Tommasi, L Rastrelli
1Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Via Ponte Don Melillo di Fisciano, Salerno, 84084 Italy. annacap@unisa.it
Phytotherapy Research : PTR
|December 13, 2000
Abstract:
The present study examines the effect of four new protopine alkaloids (1-4) isolated and purified from the aerial parts of Aristolochia constricta (Aristolichiaceae) on morphine withdrawal in vitro. The results of our experiments indicate that the pure compounds (1-4) significantly and in a concentration-dependent manner reduced the morphine withdrawal. The results of the present study suggest that these new protopine alkaloids may be potential anti-addictive agents.