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Increase in blood volume during dialysis without ultrafiltration.

R W Nette1, E Akçahüseyin, H P Krepel

  • 1Department of Internal Medicine, University Hospital Rotterdam-Dijkzigt, Rotterdam, The Netherlands.

Blood Purification
|December 15, 2000
PubMed
Summary

Diffusive dialysis, without ultrafiltration, increases relative blood volume (RBV) in hemodialysis patients. This finding may help explain why combined dialysis and ultrafiltration cause more hypotension episodes.

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Area of Science:

  • Nephrology
  • Cardiovascular Physiology

Background:

  • Combined dialysis and ultrafiltration can cause hypotension more frequently than isolated ultrafiltration.
  • Decreased plasma volume preservation is a suspected cause of hypotension during combined treatments.

Purpose of the Study:

  • To evaluate the effects of diffusive dialysis on relative blood volume (RBV) changes.
  • To investigate the relationship between diffusive dialysis and hemodynamic stability.

Main Methods:

  • Studied six stable hemodialysis patients undergoing 10 sessions of 4-hour bicarbonate diffusive dialysis.
  • Continuously monitored relative blood volume (RBV) using hematocrit measurements.
  • Assessed blood pressure and heart rate throughout the dialysis sessions.

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Main Results:

  • Relative blood volume (RBV) increased by 2.4% in the first hour and 2.5% in the second hour.
  • RBV returned to baseline levels by the end of the dialysis session.
  • No significant changes in blood pressure or heart rate were observed.

Conclusions:

  • Diffusive dialysis, when performed without ultrafiltration, leads to an increase in relative blood volume (RBV).
  • This RBV increase may be attributed to decreased vascular resistance or altered regional blood distribution.
  • Findings suggest a potential mechanism for hypotension observed during combined dialysis and ultrafiltration therapies.