Animal experimentation: a rational approach towards drug development

Area of Science:

• Pharmacology and Toxicology
• Medical History
• Bioethics

Background:

• Human observation of animals for study dates back to prehistory.
• The earliest recorded use of live animals in research was in Alexandria around 300 B.C.

Purpose of the Study:

• To describe experimental work on animals that contributed to drug discovery and development.
• To highlight the role of animal experimentation in creating drugs for human and animal health.
• To examine legislation and ethical viewpoints on animal experimentation, with a focus on India.

Main Methods:

• Review of historical records and scientific literature on animal experimentation.
• Analysis of the contribution of animal studies to major drug classes.
• Examination of legislative frameworks and ethical debates surrounding animal research.

Main Results:

• Animal experimentation has been fundamental to numerous drug discoveries and advancements in pharmacology.
• Legislation and ethical discussions surrounding animal research vary globally, with specific attention to India.

Conclusions:

• Animal research remains a cornerstone of therapeutic development.
• The article aims to foster a rational debate on the future of animal experimentation and its ethical implications.