Aromatic compound-dependent Brucella suis is attenuated in both cultured cells and mouse models
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Microscopy-based Assays for High-throughput Screening of Host Factors Involved in Brucella Infection of Hela Cells
Published on: August 5, 2016
V Foulongne1, K Walravens, G Bourg
1INSERM U431, Faculté de Médecine, 30900 Nîmes, France.
Infection and Immunity
|December 19, 2000
Abstract:
The aroC gene of the facultative intracellular pathogen Brucella suis was cloned and sequenced. The cloned aroC gene complements Escherichia coli and Salmonella enterica serovar Typhimurium aroC mutants. A B. suis aroC mutant was found to be unable to grow in a defined medium without aromatic compounds. The mutant was highly attenuated in tissue culture (THP1 macrophages and HeLa cells) and murine virulence models.
