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Peritoneal fluid concentrations of interleukin-11 in women with endometriosis
M R Gazvani1, M Bates, G Vince
1Reproductive Medicine Unit, Liverpool Women's Hospital, Liverpool, United Kingdom. m.r.gazvani@abdn.ac.uk
Objective:
To determine the peritoneal fluid concentrations of interleukin-11 (IL-11) in women with endometriosis as compared with the control group.
Design:
A prospective, controlled study.
Setting:
The obstetrics and gynecology department of a teaching hospital and a university immunology department.
Patient(S):
Sixty consecutive women undergoing laparoscopic surgery for benign gynecological indications.
Intervention(S):
Peritoneal fluid was obtained during laparoscopy, and the concentration of IL-11 was measured.
Main Outcome Measure(S):
Concentration of IL-11 in correlation with the presence of endometriosis, its stage, and the phase of the menstrual cycle.
Result(S):
IL-11 was detectable in the peritoneal fluid of 64% of women tested. Concentrations of IL-11 showed no correlation with the presence of endometriosis, the American Fertility Society stage of the disease, or the phase of the menstrual cycle.
Conclusion(S):
We found no evidence to suggest that IL-11 is involved in the pathogenesis of pelvic endometriosis.