Related Experiment Video
Updated: Aug 15, 2026

A Protocol for Functional Assessment of Whole-Protein Saturation Mutagenesis Libraries Utilizing High-Throughput Sequencing
Published on: July 3, 2016
Balance of fitnesses maintaining polymorphisms in two-locus genetic systems
1Department of Biology, University of Maryland, College Park, Maryland, USA.
Abstract:
Maintenance of a stable two-locus polymorphism is analyzed statistically by fitting a logistic regression with a quadratic function of genotypic fitnesses to the probability for a fitness set to maintain a polymorphism. The regression is fitted using a data set containing information on stable equilibria maintained by 32,00 randomly generated fitness sets with three recombination values (0. 005, 0.05, 0.5). Fitted logistic regressions discriminate with 88 to 90% accuracy between fitness sets maintaining and not maintaining a stable internal equilibrium, which implies the existence of a fitness structure (balance of fitnesses) maintaining a two-locus polymorphism. Aspects of the balance of fitnesses revealed by logistic regressions are discussed. It is demonstrated that logistic regression also discriminates between types of a stable polymorphism: globally stable polymorphism, several simultaneously stable polymorphisms, and stable equilibria in addition to a polymorphic one, which implies that different balances of fitnesses are responsible for the maintenance of different types of polymorphism.
Related Concept Videos
Genetic Lingo
What is Population Genetics?
Hardy-Weinberg Principle
Mutation, Gene Flow, and Genetic Drift
Law of Segregation
Genetic Variation
Genes exist in different versions called alleles, which...

