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Imaging G-protein Coupled Receptor (GPCR)-mediated Signaling Events that Control Chemotaxis of Dictyostelium Discoideum
Published on: September 20, 2011
Signalling molecules involved in cellular differentiation during Dictyostelium morphogenesis
1Department of Microbiology and Immunology, The University of British Columbia, Room 300, 6174 University Boulevard, Vancouver, BC, V6T 1Z3, Canada. gweeks@interchange.ubc.ca
Abstract:
GSK-3, Dd-STATa, PKA, rZIP and Ras all play important roles in cell type determination of Dictyostelium discoideum. The fact that homologs of these proteins also function in metazoan development emphasizes the importance of Dictyostelium as a model microbial organism for studying the molecular mechanisms that regulate development. The recent elaboration of the central role for GSK-3 in cell type determination has been of particular importance. The stimulatory effect of extracellular cAMP on GSK-3 activity has been shown to act through the cell surface receptor cAR3 and a tyrosine protein kinase ZAK1, which directly activates and phosphorylates GSK-3. Several proteins, including Dd-STATa, have been identified as substrates for GSK-3, and are therefore potential transducers of the signals involved in cell type determination.
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