Related Experiment Videos
The 8p12 myeloproliferative disorder. t(8;19)(p12;q13.3): a novel translocation involving the FGFR1 gene
F Mugneret1, M Chaffanet, M Maynadié
1Laboratoires de Cytogénétique et d'Hématologie, Hématologie clinique, Hôpital du Bocage, Dijon, France.
British Journal of Haematology
|December 21, 2000
Abstract:
Translocations affecting the chromosomal locus 8p12 are hallmarks of an atypical stem cell myeloproliferative disorder. These events disrupt the fibroblast growth factor receptor 1 (FGFR1) gene and fuse the FGFR1 C-terminus catalytic domain with unrelated proteins. Here, we report on the characterization of the 19q13.3 locus as the fifth FGFR1 chromosomal partner.