Antioxidants and coronary artery disease

The protective role of antioxidants in experimental models of atherosclerosis is only partially confirmed by studies in man. Observational and epidemiologic data, as well as randomized trials failed to provide clear cut indications, because of mixed results on the protective role of antioxidants against cardiovascular diseases. In spite of the lack of a general consensus, recent data reinforce the concept that a regular intake of antioxidants present in food limits the progression of atherosclerosis. When it will be possible to monitor the efficacy of any antioxidant therapy with validated markers of oxidation, the potential influence of vitamins and antioxidants on coronary artery disease may eventually be resolved.