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Biomarkers as surrogates for cancer development.
E Hawk1, J L Viner, J A Lawrence
1DCP/GI and Other Cancer Research Group, National Cancer Institute, EPN, Suite 201, 6130 Executive Boulevard, Bethesda, MD 20892-7322, USA. hawke@mail.nih.gov
Current Oncology Reports
|December 21, 2000
Summary
Biomarkers aid chronic disease management for early diagnosis and treatment assessment. This study presents a step-wise approach for developing tissue-based biomarkers, valuable for research and clinical trials.
Area of Science:
- Biomedical Science
- Pathology
- Molecular Biology
Background:
- Biomarkers are crucial for managing chronic diseases, enabling early diagnosis and treatment evaluation.
- They provide insights into biological processes at multiple organizational levels, from molecular to tissue.
Purpose of the Study:
- To present a structured approach for developing tissue-based biomarkers.
- To highlight the utility of these biomarkers as molecular targets and clinical trial endpoints.
Main Methods:
- A step-wise methodology for the development of tissue-based biomarkers is described.
- Focus on translating molecular insights into tangible tissue markers.
Main Results:
- The presented approach facilitates the creation of novel tissue-based biomarkers.
- These biomarkers offer potential for scientific investigation and clinical application.
Conclusions:
- Tissue-based biomarkers are valuable tools in chronic disease management and research.
- The development framework supports their use as targets for intervention and as endpoints in clinical trials.