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Updated: Jul 14, 2026

The Forced Swim Test as a Model of Depressive-like Behavior
Published on: March 2, 2015
Sexual side effects of antidepressant drugs
A J Gelenberg1, P Delgado, H G Nurnberg
1Department of Psychiatry, Arizona Health Sciences Center, 1501 North Campbell Avenue, PO Box 245002, Tucson, AZ 85724-5002, USA. alang@u.arizona.edu
Abstract:
Sexual functioning often suffers during depression, although depressed people continue to value sex. Many popular antidepressants further impair sexual functioning, with highly serotonergic agents affecting orgasm and libido prominently. This paper addresses clinical assessment of sexual side effects from antidepressant drugs and reviews treatment strategies, including purported antidotes. We pay particular attention to sildenafil, on which there are impressive data and ongoing controlled studies.
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