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Suicide Risk in Glioblastoma Multiforme: A Brief Review of Risk Factors, Screening, and Prevention
Nick Waldvogel1, Hyo Ryu2, Michelle Riba3
1Department of Psychiatry, University of Michigan, Ann Arbor, MI, 48109, USA. nwaldvog@umich.edu.
Current Psychiatry Reports
|August 12, 2026
Summary
Glioblastoma patients face high suicide risk, especially within the first year post-diagnosis. Identifying risk factors and implementing interventions like psychotherapy and caregiver support are crucial for mitigation.
Area of Science:
- Neuro-oncology
- Psychiatry
- Public Health
Background:
- Glioblastoma multiforme (GBM) is an aggressive brain tumor with poor prognosis and significant psychological distress.
- Patients with GBM exhibit elevated suicide risk compared to other cancer patients, necessitating focused research.
- Existing literature lacks updated reviews on suicide risk in GBM patients.
Purpose of the Study:
- To review current evidence on suicide risk factors in GBM patients.
- To summarize effective screening approaches for suicide risk.
- To outline evidence-based suicide mitigation strategies for GBM patients.
Main Methods:
- Comprehensive literature review of studies on glioblastoma multiforme and suicide.
- Analysis of demographic, clinical, and treatment-related factors associated with suicide risk.
- Evaluation of screening tools and intervention strategies.
Main Results:
- Suicide risk is highest in the first year post-GBM diagnosis, associated with older age, male gender, and supratentorial tumors.
- Neurocognitive decline, functional status, demoralization, and treatment side effects (corticosteroids, chemotherapy, radiotherapy) may contribute to risk.
- Screening tools (PHQ-9, HADS, C-SSRS) combined with clinical interviews are effective; interventions include psychotherapy, safety planning, and caregiver support.
Conclusions:
- GBM diagnosis carries a significantly higher suicide rate than most cancers.
- Demographic and tumor features linked to suicide risk are identified, alongside effective interventions.
- Further research should explore broader oncology risk factors in GBM cohorts to refine suicide prevention strategies.
