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Atherosclerosis and systemic lupus erythematosus.

M Urowitz1, D Gladman, I Bruce

  • 1University of Toronto, Director Centre of Prognosis Studies in The Rheumatic Diseases and The University of Toronto Lupus Clinic, The Toronto Hospital, Western Division, 399 Bathurst Street, 1-318, Toronto, Ontario, M5T 2S8, Canada. urowitz@utoronto.ca

Current Rheumatology Reports
|December 21, 2000
PubMed
Summary

Systemic lupus erythematosus (SLE) accelerates atherosclerosis, increasing cardiovascular risks like heart attack in young women. Understanding these mechanisms may enable earlier diagnosis and prevention strategies.

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Area of Science:

  • Rheumatology
  • Cardiology
  • Immunology

Background:

  • Systemic lupus erythematosus (SLE) is associated with increased mortality and morbidity.
  • Accelerated atherosclerosis is a significant clinical manifestation in SLE patients.
  • Cardiovascular events like myocardial infarction are observed in young SLE patients.

Purpose of the Study:

  • To investigate the mechanisms behind accelerated atherosclerosis in SLE.
  • To identify risk factors contributing to cardiovascular disease in SLE.
  • To explore potential preventive strategies for atherosclerosis in SLE.

Main Methods:

  • Clinical observation of cardiovascular events in SLE patients.
  • Postmortem examination findings related to atherosclerosis.

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  • Analysis of contributing factors including disease activity, anticardiolipin syndrome, and corticosteroid use.

    • Main Results:

    • Accelerated atherosclerosis is a recognized complication in SLE, seen both clinically and pathologically.
    • Disease activity, anticardiolipin syndrome, and corticosteroid-induced hyperlipidemia are implicated in its development.
    • SLE may act as an independent risk factor for atherosclerosis.

    Conclusions:

    • The precise mechanisms of accelerated atherosclerosis in SLE require further elucidation.
    • Antimalarials show potential in mitigating corticosteroid-induced hyperlipidemia.
    • Accumulating evidence of subclinical atherosclerosis supports earlier diagnosis and intervention in SLE patients.