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Sympathetic nervous system function in fibromyalgia.

F Petzke1, D J Clauw

  • 1Division of Rheumatology, Immunology, and Allergy, Georgetown University Medical Center, LL Gorman Building, 3800 Reservoir Road NW, Washington, DC 20007. petzkef@gusun.georgetown.edu

Current Rheumatology Reports
|December 21, 2000
PubMed
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This review examines the sympathetic nervous system

Area of Science:

  • Neuroscience
  • Autonomic Nervous System Research
  • Fibromyalgia Studies

Background:

  • The sympathetic nervous system regulates the body's stress response.
  • Dysregulation of the sympathetic nervous system is implicated in fibromyalgia (FM).
  • Understanding autonomic function is crucial for FM research.

Purpose of the Study:

  • To review studies on sympathetic nervous system function in fibromyalgia.
  • To highlight functional assessment methods for sympathetic activity in FM.
  • To discuss the relevance of autonomic function in related chronic pain disorders.

Main Methods:

  • Review of existing literature on sympathetic nervous system and fibromyalgia.
  • Analysis of functional assessment techniques including heart rate variability.

Related Experiment Videos

  • Examination of biochemical and psychophysical responses to stressors.

    • Main Results:

    • Evidence suggests altered sympathetic nervous system function in fibromyalgia patients.
    • Heart rate variability and stressor responses are key indicators of autonomic dysfunction.
    • Autonomic dysfunction is also observed in related conditions like chronic fatigue syndrome, IBS, and migraine.

    Conclusions:

    • The sympathetic nervous system plays a significant role in the pathophysiology of fibromyalgia.
    • Specific assessment methods are vital for future research into FM autonomic dysfunction.
    • Shared autonomic mechanisms may link fibromyalgia with other functional somatic syndromes.