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Related Experiment Videos

Macrophagic myofasciitis.

P Cherin1, R K Gherardi

  • 1Service de Médecine Interne, CHU Pitié-Salpétrière, 47 Bd de l'hôpital, 75013 Paris, France. patrick.cherin@psl.ap-hop-paris.fr

Current Rheumatology Reports
|December 21, 2000
PubMed
Summary
This summary is machine-generated.

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Macrophagic myofasciitis is an unusual inflammatory myopathy characterized by specific muscle biopsy findings. Patients often experience myalgias and weakness, improving with steroid therapy.

Area of Science:

  • Neurology
  • Immunology
  • Pathology

Background:

  • Macrophagic myofasciitis (MMF) is an inflammatory myopathy first described in 1993.
  • It has been increasingly reported in French myopathologic centers.
  • This study details the characteristics of the first 22 MMF patients.

Purpose of the Study:

  • To describe the clinical, laboratory, and pathological features of macrophagic myofasciitis.
  • To differentiate MMF from other myopathies.
  • To discuss potential etiologies of MMF.

Main Methods:

  • Retrospective analysis of 22 patients with a presumptive diagnosis of other myopathies.
  • Clinical assessment including symptoms and laboratory findings (CK, ESR, EMG).
  • Detailed muscle biopsy analysis focusing on cellular infiltration and muscle fiber integrity.

Related Experiment Videos

Main Results:

  • The 22 patients (M/F ratio 1:3) presented with myalgias (91%), arthralgias (68%), asthenia (55%), weakness (45%), and fever (32%).
  • Biopsies revealed characteristic centripetal infiltration by monocyte/macrophage lineage cells (CD68+) with PAS-positive content, lacking necrosis or mitotic figures.
  • Elevated CK (50%), ESR (37%), and myopathic EMG (35%) were noted. Infectious causes were ruled out.

Conclusions:

  • Macrophagic myofasciitis presents with distinct clinical and pathological features, differentiating it from other myopathies like sarcoid myopathy.
  • The condition appears to respond to steroid therapy, sometimes combined with antibiotics.
  • The etiology remains unclear, prompting further investigation into potential causes.