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Combination propofol-ketamine anaesthesia in sick neonates.

¹Loyola University Medical Center, Department of Anesthesiology, Maywood, IL 60153, USA.

Paediatric Anaesthesia

|December 21, 2000

Summary

This study explored a propofol-ketamine (PROP-KET) anesthetic combination for critically ill neonates. The PROP-KET mixture proved effective and safe for intravenous anesthesia in opioid-tolerant infants.

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Area of Science:

Anesthesiology
Neonatal Intensive Care

Background:

Critically ill neonates often require anesthesia.
Opioid tolerance is common in this patient population, complicating anesthetic choices.
Availability of anesthesia vaporizers can be limited in neonatal intensive care settings.

Observation:

Two opioid-tolerant neonates received anesthesia using a combination of propofol (PROP) and ketamine (KET).
A mixture of 3 mg KET per 10 mg PROP was administered intravenously.
Infusion rates for PROP were 100-150 microg x kg(-1) x min(-1), with concurrent KET at 30-45 microg x kg(-1) x min(-1).

Findings:

Total doses administered were 12-15 mg x kg(-1) for PROP and 3.6-4.5 mg x kg(-1) for KET.
Both neonates maintained hemodynamic stability throughout their surgical procedures.
The PROP-KET combination was found to be a rational and effective anesthetic approach.

Implications:

This PROP-KET anesthetic strategy offers a viable option for critically ill, opioid-tolerant neonates.
It provides a safe and effective alternative when anesthesia vaporizers are unavailable.
Further research may explore broader applications of this combination in neonatal anesthesia.

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