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Related Experiment Videos

Continuous haemofiltration in the intensive care unit.

R Bellomo1, C Ronco

  • 1Austin & Repatriation Medical Centre, Melbourne, Victoria, Australia. rb@austin.unimelb.edu.au

Critical Care (London, England)
|December 21, 2000
PubMed
Summary
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Continuous renal replacement therapy (CRRT) has evolved significantly since 1977, offering physiological benefits over intermittent hemodialysis. This blood purification method shows promise for managing septic shock in intensive care units.

Area of Science:

  • Nephrology
  • Critical Care Medicine
  • Intensive Care Unit (ICU) Management

Background:

  • Continuous renal replacement therapy (CRRT) was introduced in 1977 for fluid overload unresponsive to diuretics in the ICU.
  • CRRT has seen substantial technical and conceptual advancements, becoming widely available in tertiary ICUs globally.
  • In some regions, CRRT has largely superseded intermittent hemodialysis (IHD).

Purpose of the Study:

  • To review the evolution and current status of CRRT.
  • To discuss the physiological advantages and ongoing controversies surrounding CRRT compared to IHD.
  • To explore the role of CRRT and blood purification in managing septic shock.

Main Methods:

  • Review of historical development and technological advancements in CRRT.

Related Experiment Videos

  • Comparison of CRRT with intermittent hemodialysis (IHD) regarding efficacy and outcomes.
  • Examination of experimental evidence for CRRT in septic shock management.

    • Main Results:

    • CRRT machines and venovenous therapies with blood pumps represent significant technical progress.
    • While mortality benefits versus IHD remain debated, CRRT is considered physiologically superior.
    • CRRT has stimulated interest in blood purification, especially for septic states.

    Conclusions:

    • CRRT has evolved from a niche treatment to a cornerstone of critical care, particularly for fluid management.
    • The physiological benefits of CRRT are increasingly recognized, despite ongoing discussions on mortality.
    • CRRT and broader blood purification strategies hold significant promise for treating critically ill patients, including those with septic shock.