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iProClass: an integrated, comprehensive and annotated protein classification database.

C H Wu1, C Xiao, Z Hou

  • 1Protein Information Resource, National Biomedical Research Foundation, Georgetown University Medical Center, 3900 Reservoir Road, NW Washington, DC 20007-2195, USA. wuc@nbrf.georgetown.edu

Nucleic Acids Research
|January 11, 2000
PubMed
Summary
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The iProClass database offers integrated protein family information, structural and functional features, and extensive cross-database links. This resource aids in protein classification and genomic research.

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Proteomics

Background:

  • Protein classification is crucial for understanding biological functions.
  • Existing databases like ProClass provide valuable protein family information.
  • Integrated resources are needed for comprehensive protein analysis.

Purpose of the Study:

  • To present the iProClass database as an integrated resource for protein family relationships and features.
  • To enhance protein annotation and support genomic research.

Main Methods:

  • iProClass integrates PIR superfamilies and PROSITE motifs.
  • It organizes over 200,000 non-redundant proteins into superfamilies, domains, and motifs.
  • The database includes links to over 30 external databases.

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Main Results:

  • iProClass contains over 28,000 superfamilies, 2600 domains, and 1300 motifs.
  • It provides detailed annotations, including membership statistics and graphical feature display.
  • The database facilitates classification-driven annotation for protein sequence databases and genomes.

Conclusions:

  • iProClass serves as a valuable, integrated resource for protein family analysis.
  • It supports structural and functional genomic research through comprehensive data and links.
  • The database is accessible for sequence search and report retrieval.