Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

RefSeq and LocusLink: NCBI gene-centered resources.

K D Pruitt1, D R Maglott

  • 1National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A Room 6N605, 8600 Rockville Pike, Bethesda, MD 20894 USA. pruitt@ncbi.nlm.nih.gov

Nucleic Acids Research
|January 11, 2000
PubMed
Summary

The National Center for Biotechnology Information (NCBI) offers LocusLink and RefSeq resources to manage vast gene data. These tools provide a unified view of genes and reference sequences for key genomes, aiding research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pharmacogenetic allele nomenclature: International workgroup recommendations for test result reporting.

Clinical pharmacology and therapeutics·2015
Same author

A genome-wide analysis of biomineralization-related proteins in the sea urchin Strongylocentrotus purpuratus.

Developmental biology·2006
Same author

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

Nature·2002
Same author

NCBI genetic resources supporting immunogenetic research.

Reviews in immunogenetics·2002
Same author

Introducing RefSeq and LocusLink: curated human genome resources at the NCBI.

Trends in genetics : TIG·2000
Same author

NCBI's LocusLink and RefSeq.

Nucleic acids research·1999

Area of Science:

  • Genomics and Bioinformatics
  • Molecular Biology
  • Computational Biology

Background:

  • Thousands of genes have been identified, with many more predicted by large-scale sequencing projects.
  • The increasing volume of scientific literature necessitates organized gene and reference sequence information.
  • Existing data is fragmented, hindering comprehensive gene research.

Purpose of the Study:

  • To introduce and describe the LocusLink and RefSeq resources provided by the NCBI.
  • To highlight how these resources address the critical need for gene and reference sequence directories.
  • To explain the utility of LocusLink and RefSeq in supporting various areas of gene research.

Main Methods:

  • LocusLink consolidates gene-specific information, creating a central access point for model organisms.

Related Experiment Videos

  • RefSeq establishes reference sequence standards for genomes, transcripts, and proteins.
  • The study discusses human, mouse, and rat mRNA RefSeqs and their corresponding proteins.

    • Main Results:

    • LocusLink provides gene-centric access for fruit fly, human, mouse, rat, and zebrafish.
    • RefSeq offers standardized reference sequences for genomes, transcripts, and proteins.
    • Combined, LocusLink and RefSeq present a non-redundant view of genes and loci.

    Conclusions:

    • LocusLink and RefSeq are crucial NCBI resources for managing and accessing gene and reference sequence data.
    • These integrated resources support diverse research areas including gene families, variation, expression, and annotation.
    • The NCBI provides a comprehensive solution for the growing challenges in genomic data organization and utilization.