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The European Large Subunit Ribosomal RNA Database.

J Wuyts1, P De Rijk, Y Van de Peer

  • 1Departement Biochemie, Universiteit Antwerpen (UIA), Universiteitsplein 1, B-2610 Antwerpen, Belgium.

Nucleic Acids Research
|January 11, 2000
PubMed
Summary

The European Large Subunit Ribosomal RNA Database offers aligned ribosomal RNA sequences and secondary structures. This resource aids researchers studying ribosomal RNA evolution and function.

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Area of Science:

  • Molecular Biology
  • Bioinformatics
  • Genomics

Background:

  • Ribosomal RNA (rRNA) is crucial for protein synthesis and cellular function.
  • Comparative analysis of rRNA sequences provides insights into evolutionary relationships and functional mechanisms.
  • Access to curated and aligned rRNA sequence data is essential for researchers.

Purpose of the Study:

  • To create a centralized, comprehensive database of large subunit ribosomal RNA (LSU rRNA) sequences.
  • To provide aligned LSU rRNA sequences with associated secondary structure information.
  • To facilitate research in molecular biology, evolution, and genomics by offering a valuable data resource.

Main Methods:

  • Compilation of complete or nearly complete LSU rRNA sequences from public databases.

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  • Alignment of sequences using established bioinformatics methods.
  • Derivation of secondary structures through comparative sequence analysis.
  • Integration of taxonomic and literature reference data for each sequence.

    • Main Results:

    • A curated collection of aligned LSU rRNA sequences is now available.
    • Secondary structure information derived from comparative analysis is included for each sequence.
    • Associated taxonomic and literature data enhance the utility of the database.

    Conclusions:

    • The European Large Subunit Ribosomal RNA Database serves as a valuable resource for the scientific community.
    • The database facilitates comparative and evolutionary studies of LSU rRNA.
    • Easy accessibility via a WWW server promotes widespread use and further research.