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DIP: The Database of Interacting Proteins: 2001 update.
I Xenarios1, E Fernandez, L Salwinski
1UCLA-DOE Laboratory of Structural Biology and Molecular Medicine, Molecular Biology Institute, PO Box 951570, UCLA, Los Angeles, CA 90095-1570, USA.
Nucleic Acids Research
|January 11, 2000
Summary
The Database of Interacting Proteins (DIP) has significantly expanded, now documenting 3472 protein interactions and 2659 proteins. New interactive tools enhance the study of complex protein interaction networks.
Area of Science:
- Biochemistry
- Bioinformatics
- Molecular Biology
Background:
- Protein-protein interactions are fundamental to cellular processes.
- Databases are crucial for organizing and accessing interaction data.
- The Database of Interacting Proteins (DIP) curates experimentally determined interactions.
Purpose of the Study:
- To report the growth and updates of the DIP database.
- To introduce new tools for analyzing protein interaction networks.
Main Methods:
- Data curation of experimentally determined protein-protein interactions.
- Development of interactive visualization and navigation tools.
Main Results:
- The number of protein-protein interactions in DIP has nearly tripled since January 2000.
- The database now contains 3472 interactions and 2659 proteins.
- New interactive tools facilitate network analysis.
Conclusions:
- DIP continues to be a valuable resource for protein interaction data.
- Enhanced tools improve the accessibility and utility of the DIP database for researchers.