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The Homeodomain Resource: sequences, structures, DNA binding sites and genomic information
S Banerjee-Basu1, D W Sink, A D Baxevanis
1Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Nucleic Acids Research
|January 11, 2000
Summary
The Homeodomain Resource (Release 3.0) offers a comprehensive database of homeodomain protein family information, including sequences, structures, and genomic data. It now features DNA recognition sites for human homeodomain proteins, aiding genetic disorder research.
Area of Science:
- Genomics
- Molecular Biology
- Bioinformatics
Background:
- The homeodomain protein family plays crucial roles in development and disease.
- Access to comprehensive and integrated data is essential for studying these proteins.
Purpose of the Study:
- To update and expand the Homeodomain Resource with the latest data.
- To enhance the resource with DNA recognition site information for human homeodomain proteins.
Main Methods:
- Compilation of non-redundant protein sequences, 3D structures, and genomic information.
- Integration of data from source databases with hyperlinks.
- Development of a user-friendly search engine with a graphical interface.
- Inclusion of DNA recognition sites for human homeodomain proteins.
Main Results:
- Release 3.0 contains 795 full-length homeodomain-containing sequences.
- Includes 32 experimentally-derived structures and 143 homeo-box loci linked to human genetic disorders.
- New addition of DNA recognition sites for all human homeodomain proteins.
Conclusions:
- The updated Homeodomain Resource provides a valuable, integrated platform for researchers.
- Facilitates the study of homeodomain proteins, their functions, and their implications in genetic disorders.
- The resource is freely accessible online, promoting wider research engagement.