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Related Experiment Videos

Centrioles and kinetosomes: form, function, and evolution.

M J Chapman1, M F Dolan, L Margulis

  • 1Department of Biology, College of the Holy Cross, Worcester, Massachusetts 01610, USA.

The Quarterly Review of Biology
|December 28, 2000
PubMed
Summary
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Centrioles and kinetosomes are homologous structures, acting as microtubule organizing centers (MTOCs) across diverse organisms. Their conserved protein components suggest ancient origins and diverse evolutionary pathways.

Area of Science:

  • Cell Biology
  • Cytology
  • Evolutionary Biology

Background:

  • The Henneguy-Lenhossék theory (1899) posits centrioles and kinetosomes as homologous structures.
  • Centrioles form centrosomes in animal cells and develop into kinetosomes (basal bodies) for cilia.
  • Microtubule organizing centers (MTOCs) are crucial for cellular structure and division in eukaryotes.

Purpose of the Study:

  • To review literature on centrioles, kinetosomes, and MTOCs in various taxa.
  • To evaluate the validity of the Henneguy-Lenhossék theory in light of modern data.
  • To explore evolutionary models for centriole-kinetosome origins.

Main Methods:

  • Literature review of ultrastructural and molecular data.
  • Analysis of conserved protein sequences (e.g., gamma-tubulin, pericentrin, centrin family).

Related Experiment Videos

  • Comparison of endogenous and exogenous (bacterial symbiont) evolutionary models.

    • Main Results:

    • Centrioles and kinetosomes are confirmed as homologous, developmentally distinct MTOCs.
    • Key protein components are conserved across animals, plants, protists, and fungi.
    • The orthogonal arrangement of centrioles in centrosomes may have an ancient origin.

    Conclusions:

    • The Henneguy-Lenhossék theory remains a valid framework for understanding centriole-kinetosome biology.
    • Conserved proteins highlight the ancient and fundamental role of these MTOCs.
    • Both endogenous and exogenous evolutionary pathways are plausible for centriole-kinetosome evolution.