Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in the mitotic cycle induced by alpha-solanine.

D Kirk, U Mittwoch

    Humangenetik
    |January 1, 1975
    PubMed
    Summary

    Alpha-solanine affects human fibroblast growth; low doses stimulate cell proliferation by shortening the G1 phase, while high doses inhibit growth and cause G2 phase accumulation. This dual effect suggests alpha-solanine may act as a human teratogen.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Magnetically localized and wash-free fluorescent immuno-assay: From a research platform (MLFIA) to a multiplexed POC system (MagIA).

    SLAS technology·2024
    Same author

    Magnetically localized and wash-free fluorescence immunoassay (MLFIA): proof of concept and clinical applications.

    Lab on a chip·2023
    Same author

    Systematic review: adrenal insufficiency secondary to swallowed topical corticosteroids in eosinophilic oesophagitis.

    Alimentary pharmacology & therapeutics·2018
    Same author

    Effects of prepartum dietary cation-anion difference on aspects of peripartum mineral and energy metabolism and performance of multiparous Holstein cows.

    Journal of dairy science·2017
    Same author

    "Is TGfU a Model Only Test Pilots Can Fly?": Teacher-Coach Development in Game-Centered Approaches.

    Research quarterly for exercise and sport·2016
    Same author

    A Method for Investigating "Instructional Familiarity" and Discerning Authentic Learning.

    Annals of medical and health sciences research·2016

    Area of Science:

    • Toxicology
    • Cell Biology
    • Developmental Biology

    Background:

    • Alpha-solanine is a glycoalkaloid found in plants like potatoes.
    • Its effects on human cell growth and development are not fully understood.

    Purpose of the Study:

    • To investigate the impact of alpha-solanine on cultured human fibroblast proliferation.
    • To elucidate the cell cycle mechanisms underlying alpha-solanine's effects.
    • To assess the potential teratogenic risk of alpha-solanine.

    Main Methods:

    • Cultured human fibroblasts were treated with varying concentrations of alpha-solanine.
    • Autoradiography was used to analyze cell cycle phase durations.
    • Feulgen microdensitometry assessed cell cycle distribution.

    Main Results:

    • Low alpha-solanine concentrations (less than 30 µg/mL) stimulated fibroblast growth by shortening the G1 phase.
    • High alpha-solanine concentrations inhibited cell growth and led to abnormal G2 phase accumulation.
    • The stimulatory effect at low doses mimicked that of sex hormones on target tissues.

    Conclusions:

    • Alpha-solanine exhibits dose-dependent effects on human fibroblast proliferation.
    • Its ability to modulate cell cycle progression and potentially cause developmental abnormalities suggests a teratogenic role.
    • Further research is warranted to confirm the teratogenic potential in vivo.

    Related Experiment Videos