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Polymer-supported tetrafluorophenol: a new activated resin for chemical library synthesis
J M Salvino1, N V Kumar, E Orton
1Lead Discovery Department, Rhone Poulen Rorer, Collegeville, Pennsylvania 19426, USA.
Journal of Combinatorial Chemistry
|January 11, 2000
Abstract:
A new tetrafluorophenol activated resin that facilitates the use of 19F NMR to quantitate loading is presented. This new resin provides a useful tool for acylation, and a novel activated polymeric sulfonate ester to generate sulfonamides. This activated resin reacts with a wide scope of N-nucleophiles including primary and secondary amines, and anilines. This new activated resin methodology provides a powerful tool for pure single-compound library synthesis.