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Randomised, prospective, controlled trial comparing tropisetron with metoclopramide and placebo in controlling
S R Muhammad1, S Z Abbas, S Q Abbas
1Department of Surgery, Baqai Medical University, Karachi.
Objective:
To compare the results of Tropisetron, Metoclopramide and placebo on postoperative nausea and vomiting in patients undergoing minilaparotomy cholecystectomy.
Setting:
Patients operated for minilaparotomy cholecystectomy in two private hospitals in Karachi.
Subjects:
Fifty consecutive patients of all ages and both sex who had simple cholelithiasis and underwent minilaparotomy cholecystectomy by a single surgeon.
Main Outcome Measures:
Postoperative nausea and vomiting (PONV) at 2 hours and within 24 hours and requirement of rescue antiemetic.
Results:
Tropisetron was better than Metoclopramide and placebo in controlling postoperative nausea and vomiting.
Conclusion:
Tropisetron when given at induction at a dose of 2 mg. intravenously prevents PONV better than Metoclopramide and placebo in 2 hours and 24 hours. It also reduces the need for rescue antiemetic significantly.
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