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[Anuria in HIV+ patients treated with indinavir]
M J Rebassa Llull1, A Conte Visús, F Grases Freixedas
1Servicio de Urología, Hospital Son Dureta, Palma de Mallorca, España.
Objective:
Two cases of oliguric acute renal failure in HIV+ patients treated with indinavir are described.
Methods:
Patient evaluation included blood analysis, urinalysis, abdominal x-rays, renal US and IVP.
Results:
Both cases resolved with discontinuation of drug therapy, administration of fluids and urine acidification.
Conclusions:
Severe acute renal failure is an uncommon complication in HIV+ patients treated with indinavir. This drug has a great tendency to precipitate in urine. The severity of the crystalluria depends on the drug dose and urinary pH, and can cause tubulointerstitial nephritis and urinary calculi with obstruction of the urinary tract.