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Related Experiment Videos

Experience with tissue heart valves.

M I Ionescu, A Abid, G H Wooler

    Israel Journal of Medical Sciences
    |February 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Tissue valves for heart valve replacement show varied outcomes. Preserved pericardium in the aortic position yielded the best results, offering potential as a heart valve substitute.

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    Area of Science:

    • Cardiovascular Surgery
    • Biomaterials Science
    • Transplantation Immunology

    Background:

    • Tissue valves have been explored for heart valve replacement.
    • Early experiences with preserved heterologous aortic valves showed significant failure rates.
    • The mechanical vulnerability and rejection of heterologous aortic valves were observed.

    Purpose of the Study:

    • To analyze the long-term performance of various tissue valves used in heart valve replacement.
    • To compare the efficacy of different tissue types (fascia lata, pericardium) and their placement (aortic, mitral, tricuspid).
    • To evaluate the potential of preserved heterologous pericardium as an adequate heart valve substitute.

    Main Methods:

    • Analysis of 87 patients receiving preserved heterologous aortic valves (1967-1969).

    Related Experiment Videos

  • Evaluation of 241 patients receiving autologous/homologous fascia lata or heterologous pericardium valves (past five years).
  • Follow-up periods ranged from 7 to 62 months, with clinical and hemodynamic assessments.

    • Main Results:

    • Heterologous aortic valves had a 27% failure rate among operative survivors.
    • Pericardial valves in the aortic position demonstrated the best function.
    • Autologous fascial valves in the mitral position showed the worst results, with six failures.
    • Low incidence of thromboembolism observed without anticoagulant use.

    Conclusions:

    • Preserved heterologous pericardium shows promise as a heart valve substitute, particularly in the aortic position.
    • Significant differences in valve function exist based on tissue type and implantation site.
    • Further research into tissue valve performance and biocompatibility is warranted.