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Related Experiment Videos

Synaptic plasticity: taming the beast.

L F Abbott1, S B Nelson

  • 1Department of Biology and Volen Center, Brandeis University, Waltham, Massachusetts 02454-9110, USA. abbott@brandeis.edu

Nature Neuroscience
|December 29, 2000
PubMed
Summary
This summary is machine-generated.

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Global regulatory processes are crucial for neural network function, complementing Hebbian plasticity. This review explores synaptic scaling, spike-timing dependent plasticity, and synaptic redistribution as key regulatory mechanisms.

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Cellular Neuroscience

Background:

  • Synaptic plasticity, including Hebbian forms like long-term potentiation and depression, underpins learning and memory.
  • Realistic neural network models require global activity regulation alongside synapse-specific plasticity.

Purpose of the Study:

  • To review novel mechanisms that regulate neuronal and network activity.
  • To discuss the functional implications of these regulatory processes in conjunction with Hebbian plasticity.

Main Methods:

  • Literature review of recent experimental results.
  • Analysis of synaptic scaling, spike-timing dependent plasticity, and synaptic redistribution.

Main Results:

Related Experiment Videos

  • Identified three key regulatory mechanisms: synaptic scaling, spike-timing dependent plasticity, and synaptic redistribution.
  • These mechanisms complement Hebbian plasticity to control network activity.

    • Conclusions:

    • Global regulatory processes are as vital as Hebbian plasticity for neural network function.
    • Understanding these mechanisms is essential for modeling learning, memory, and neural development.