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Ageing and immortality.

M R Rose1, L D Mueller

  • 1Department of Ecology and Evolutionary Biology, University of California, Irvine 92697-2525, USA. mrrose@uci.edu

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|December 29, 2000
PubMed
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The force of natural selection explains ageing, but not late-life immortality. This study explores two theories for why some organisms may live forever, focusing on cohort heterogeneity and selection force plateaus.

Area of Science:

  • Evolutionary Biology
  • Gerontology
  • Demography

Background:

  • The force of natural selection explains the evolution of ageing.
  • A period of late-life immortality, where mortality rates plateau, remains unexplained.
  • Existing theories include cohort heterogeneity and a plateau in the force of natural selection.

Purpose of the Study:

  • To investigate the biological mechanisms behind late-life immortality.
  • To differentiate between two primary theories explaining mortality plateaus in later life.
  • To understand the interplay between development, ageing, and immortality in life-history evolution.

Main Methods:

  • Comparing survival data between more and less robust ageing cohorts.
  • Fitting survival data to mathematical models to test heterogeneity.

Related Experiment Videos

  • Manipulating the force of natural selection in laboratory populations to observe effects on mortality plateaus.

    • Main Results:

    • The study proposes testable hypotheses for two competing theories of late-life immortality.
    • Methodologies are outlined for empirical testing of these theories.
    • Potential for significant insights into life-history evolution is highlighted.

    Conclusions:

    • Late-life immortality presents a significant puzzle in evolutionary biology.
    • Testing cohort heterogeneity and selection force plateaus can elucidate this phenomenon.
    • This research is crucial for understanding the complete life-history spectrum from development to potential immortality.