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Improved synthesis of the iodine-free thyromimetic GC-1
G Chiellini1, N H Nguyen, H A Yoshihara
1Department of Pharmaceutical Chemistry, University of California, San Francisco 94143-0446, USA.
Bioorganic & Medicinal Chemistry Letters
|December 29, 2000
Abstract:
Synthesis of the TRbeta-selective thyromimetic GC-1 has been improved using methoxymethyl (MOM) and triisopropylsilyl (TiPS) substituents as phenolic protecting groups. The new synthetic route is adaptable to analogue design.