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Transient splenic accumulation of Tc-99m HMDP caused by megaloblastic anemia
M Koizumi1, T Suzuki, S Takahashi
1Department of Nuclear Medicine, Cancer Institute Hospital, Tokyo, Japan. mitsuru@jfcr.or.jp
Clinical Nuclear Medicine
|December 29, 2000
Abstract:
A case of transient splenic accumulation of the bone-seeking agent Tc-99m HMDP is reported. This effect was caused by transient megaloblastic anemia induced by 5-fluorouracil chemotherapy. The extent of splenic uptake reflected the development and severity of megaloblastic anemia. The mechanism of splenic accumulation is thought to be similar to transient iron deposition in the spleen by megaloblastic anemia.