Celiac disease in older people

Area of Science:

• Gastroenterology
• Immunology
• Internal Medicine

Background:

• Celiac disease is increasingly recognized as a spectrum of gluten sensitivity beyond classical malabsorption.
• Diagnosis is often delayed due to atypical presentations, subtle symptoms, and varied age of onset.
• Nonspecific symptoms and nutritional deficiencies, especially in older adults, can mask celiac disease.

Purpose of the Study:

• To highlight the broad spectrum of celiac disease presentations.
• To emphasize the importance of considering celiac disease in patients with nonspecific symptoms.
• To underscore the role of serological tests in improving early detection.

Main Methods:

• Review of current understanding of celiac disease clinical and histological features.
• Analysis of diagnostic challenges, including atypical presentations and age of onset.
• Evaluation of the impact of serological screening tests on diagnosis.

Main Results:

• Celiac disease presents with a wide range of clinical and histological features, not limited to malabsorption.
• Delayed diagnosis is common due to subtle, nonspecific symptoms and varied presentation.
• Serological screening tests enhance the detection of celiac disease, particularly in atypical cases.

Conclusions:

• Celiac disease diagnosis requires awareness of its diverse manifestations beyond the classical presentation.
• Early detection is crucial for timely management and prevention of complications.
• Serological screening is a valuable tool for identifying celiac disease in at-risk individuals.